Prince Frederik of Luxembourg, the youngest son of Prince Robert of Luxembourg and Princess Julie of Nassau, passed away on March 1, 2025, at the age of 22. He succumbed to POLG Mitochondrial disease, a rare genetic disorder that affects the body’s cellular energy production. His death has not only cast a shadow over the Luxembourgish royal family but has also brought attention to this little-known disease.​

Early Life and Diagnosis

Born on May 18, 2002, in Aix-en-Provence, France, Prince Frederik was a member of Luxembourg’s Grand Ducal family. He spent his early years in London before relocating to Geneva, Switzerland, in 2004, where he attended the International School of Geneva, Ecole Eden, and St. George’s School in Clarens. Despite being born with POLG Mitochondrial disease, his condition remained undiagnosed until he was 14, when symptoms became more pronounced. ​

Understanding POLG Mitochondrial Disease

POLG Mitochondrial disease is caused by mutations in the POLG gene, leading to impaired function of the mitochondrial DNA polymerase enzyme. This impairment disrupts the production of energy in cells, resulting in progressive organ dysfunction and failure, affecting the muscles, eyes, liver, heart, and brain. Diagnosing the condition is challenging due to the variability of symptoms and frequent underdiagnosis, though genetic blood tests can identify many cases.

Establishment of the POLG Foundation

In response to his diagnosis, Prince Frederik became a passionate advocate for raising awareness about POLG Mitochondrial disease. He established the POLG Foundation to support research and work towards finding a cure. Through the foundation, Frederik actively contributed to awareness efforts and created the MITO fashion line to support the foundation.

Final Moments and Family Tributes

On February 28, 2025, coinciding with Rare Disease Day, Prince Frederik gathered his family members to bid them farewell. Despite his deteriorating health, he maintained his humor and compassion, leaving his family with a final joke to uplift their spirits. His father, Prince Robert, recalled Frederik asking, “Papa, are you proud of me?” To which he affirmed, expressing immense pride in his son’s resilience and accomplishments. Prince Robert described Frederik as his “superhero,” highlighting his positivity, determination, and extraordinary strength. ​

Legacy and Continued Advocacy

Prince Frederik’s legacy extends beyond his royal lineage. His efforts in establishing the POLG Foundation have laid the groundwork for ongoing research and support for individuals affected by POLG Mitochondrial disease. His family has encouraged donations to the foundation in his memory, aiming to continue Frederik’s mission to find a cure and support those impacted by the disease. ​

Prince Frederik’s life, though tragically short, was marked by courage, compassion, and a relentless drive to make a difference. His story sheds light on the challenges faced by individuals with rare genetic disorders and underscores the importance of research and awareness. As the world mourns his loss, his legacy serves as a beacon of hope and inspiration for those affected by similar conditions.

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